P1612 LOSS OF IPM SERIAL DATA FREE

P1612 LOSS OF IPM SERIAL DATA FREE

However, since most infections occur in tissue extracellular fluid, free antibiotic concentrations in the interstitial fluid at the target site are more useful for predicting the time course of antimicrobial activity and optimal drug dosing regimens ( 14). Pharmacokinetic studies of antibiotics most often rely on the determination of total concentrations in plasma. In conclusion, IPM distribution in intraperitoneal fluid is rapid and complete both in control rats and in rats with peritonitis. However, the areas under the concentration-versus-time curve estimated in intraperitoneal fluid and blood were not significantly different in both groups, with the corresponding ratios close to unity (1.01вЂ‰В± 0.19 and 0.89 В± 0.28 in control rats and rats with peritonitis, respectively). IPM concentration profiles in intraperitoneal fluid and blood were virtually superimposed in control rats, whereas in infected animals, the mean intraperitoneal IPM concentrations were apparently slightly lower than corresponding blood levels. kg в€’1 in control rats versus 310 В± 49 ml.kg в€’1 in rats with peritonitis) or the volume of distribution (296 В± 47 ml.kg в€’1 in control rats versus 10.9 В± 2.1 ml.Intraperitoneal infection had no statistically significant effect on IPM clearance (11.9 В± 2.3 ml kg в€’1 over 30 min, microdialysis samples were collected for 120 min, and IPM concentrations were determined by high-performance liquid chromatography.IPM was infused intravenously at a dose of 30 mg Imipenem (IPM) probe recoveries were determined in each rat by retrodialysis by drug. Microdialysis probes were inserted into the jugular vein and peritoneal cavity of control rats or rats with intra-abdominal sepsis ( n = 8 in each group) induced by cecal ligation and punctures. The purpose of this study was to extend the use of microdialysis to the investigation of antibiotic distribution into the intraperitoneal fluid of rats with or without peritonitis.

P1612 loss of ipm serial data